A BETA-LACTAM FRAMEWORK AS A BETA-ALANYL DICATION EQUIVALENT - NEW SYNTHESIS OF ALPHA-AMINO-ACID N-CARBOXY ANHYDRIDES (NCAS) DERIVED FROM BETA-SUBSTITUTED ALANINES

Authors
PALOMO C AIZPURUA JM GANBOA I MANEIRO E ODRIOZOLA B
Citation
C. Palomo et al., A BETA-LACTAM FRAMEWORK AS A BETA-ALANYL DICATION EQUIVALENT - NEW SYNTHESIS OF ALPHA-AMINO-ACID N-CARBOXY ANHYDRIDES (NCAS) DERIVED FROM BETA-SUBSTITUTED ALANINES, Journal of the Chemical Society, Chemical Communications, (12), 1994, pp. 1505-1507
Citations number
21
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
12
Year of publication
1994
Pages
1505 - 1507
Database
ISI
SICI code
0022-4936(1994):12<1505:ABFAAB>2.0.ZU;2-4
Abstract
Optically pure 4-formyl-3-hydroxy beta-lactams are transformed into 4- methylaryl and 4-(2-ethylaryl) derivatives and converted into beta-sub stituted alanine-derived NCAs through oxidation and Baeyer-Villiger re arrangement of the resulting alpha-keto beta-lactams.