FMOC-AMINO ACID CHLORIDES-KOBT IN SOLID-PHASE PEPTIDE-SYNTHESIS

Authors
SIVANANDAIAH KM BABU VVS GANGADHAR BP
Citation
Km. Sivanandaiah et al., FMOC-AMINO ACID CHLORIDES-KOBT IN SOLID-PHASE PEPTIDE-SYNTHESIS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 33(7), 1994, pp. 620-623
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
33
Issue
7
Year of publication
1994
Pages
620 - 623
Database
ISI
SICI code
0376-4699(1994)33:7<620:FACISP>2.0.ZU;2-G
Abstract
Fmoc-amino acid chlorides can be used along with KOBt instead of the r outinely employed 1:1 mixture of base (TEA or DIEA) and catalyst (HOBt or Piv) in solid phase peptide synthesis. No additional base is requi red. Coupling is fast and racemization free. Thus, the opioid peptide, beta-casomorphin (Tyr-Pro-Phe-Pro-Gly) and the laminin fragment, Tyr- Ile-Gly-Ser-Arg-NH2 have been obtained in good yields as well as purit y.