ENUCLEATION COMBINED WITH HEPATIC VASCULAR EXCLUSION IS A SAFE AND EFFECTIVE ALTERNATIVE TO HEPATIC RESECTION FOR LIVER-CELL ADENOMA

Liver cell adenomas are benign, rare tumors that occur primarily in wo men with a history of oral contraceptive use. Surgical treatment is re commended to reduce the risk of sudden, unpredictable hemorrhage or ma lignant transformation, but mortality rates of 5 to 8 per cent are rep orted for major hepatic resections. This report summarizes an experien ce of eight patients with liver cell adenoma treated by enucleation or resection, alone or combined with hepatic vascular exclusion (HVE). T he latter technique, originally described in the mid-1960s, markedly r educes operative blood loss associated with hepatic resection. All eig ht patients were women of child-bearing age, and seven reported previo us oral contraceptive use. The majority of patients were asymptomatic at the time of presentation. Six patients (75%) had a single adenoma a nd the remaining two had multiple lesions. HVE was used successfully i n four patients with no perioperative mortality and reduced by nearly 50 per cent the intraoperative blood loss compared to conventional hep atic resection (1635 mL versus 3875 mL, respectively). Six evaluable p atients were followed for an average of 65 months, with no evidence of liver dysfunction or adenoma recurrence. Enucleation of liver cell ad enoma appears to be a safe alternative to formal hepatic resection and provides excellent long-term results. HVE markedly reduces operative blood loss, has no adverse effect on metabolic function, decreases the potential health risk associated with transfusion, and should be used whenever possible.