Tm. Ikramuddeen et al., A NOVEL SYNTHESIS OF 2 N-SUBSTITUTED PIPERIDONES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 33(4), 1994, pp. 362-364
The reaction of piperidones (1) with ethyl alpha-(bromomethyl)acrylate
under Reformatsky conditions furnishes, instead of the anticipated sp
iro alpha-methylene-gamma-butyrolactones (2), the N-substituted piperi
dones (3). Their structures have been determined by mass, H-1 NMR and
C-13 NMR spectral data.