ACUTE HEMORRAGIC COLITIS ASSOCIATED WITH ANTIBIOTICS - RESPONSIBILITYOF KLEBSIELLA-OXYTOCA IN ASSOCIATION WITH CLOSTRIDIUM-DIFFICILE

Except for pseudomembranous colitis, the pathogeny of colitis associat ed with antibiotics is still imprecise. Klebsiella oxytoca is supposed to be responsible for some cases of acute hemorragic colitis. Within a space of 2 months, we have been observing 2 cases of acute hemorragi c colitis after a treatment by pristinamycin. In the 2 cases, K. oxyto ca was isolated by culture from colic biopsy specimens, and the detect ion of the toxin-A of Clostridium difficile in stools was positive. As far as we know, this bacterial association has not yet been reported in this type of colitis. Although the responsibility of this bacterial association for the colitis has not been clearly established, a more systematic research on the presence of this bacterial association coul d make it possible to know its frequency which is probably under-estim ated.