HIGH-RESOLUTION MASS-SPECTROMETRY IN A LINEAR TIME-OF-FLIGHT MASS-SPECTROMETER

This paper describes a new method to achieve high-resolution mass spec tra in a linear time-of-flight mass spectrometer. Both direct and matr ix assisted laser desorption/ionization of large molecules are perform ed on this instrument. Using post-source pulse-focusing a mass resolut ion of 4600 (FWHM) has been achieved. This technique can correct high initial ion translational energies as well as long periods of ion form ation. Therefore it is predestinated to laser desorption/ionization ap plications. Experimental results will be shown demonstrating the capab ility of this new instrument to produce high-resolution ion signals. I n addition, a simple way to calibrate masses is discussed.