TRANSFORMATION OF SCHIZANDRIN INTO GOMISIN-A BY USE OF MICROBIAL O-DEMETHYLATION AND CHEMICAL-REACTIONS

Authors
KANATANI H SAKAKIBARA C TANAKA M NIITSU K IKEYA Y WAKAMATSU T MARUNO M
Citation
H. Kanatani et al., TRANSFORMATION OF SCHIZANDRIN INTO GOMISIN-A BY USE OF MICROBIAL O-DEMETHYLATION AND CHEMICAL-REACTIONS, Bioscience, biotechnology, and biochemistry, 58(6), 1994, pp. 1054-1057
Citations number
16
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
58
Issue
6
Year of publication
1994
Pages
1054 - 1057
Database
ISI
SICI code
0916-8451(1994)58:6<1054:TOSIGB>2.0.ZU;2-6
Abstract
The transformation of schizandrin (I) into gomisin A (TI) was accompli shed by use of a combination of biotransformation and chemical reactio ns. The biotransformation, microbial O-demethylation of I by Cunningha mella Echinulata var. elegans (ATCC 9245) produced two novel metabolit es [3-norschizandrin (IV) and 2-norschizandrin (VI)] and two known met abolites [gomisin T (III) and 13-norschizandrin (V)]. Among those meta bolites, compound III was derived to II by the O-demethylation with a Lewis acid in the presence of an acid scavenger, followed by methylena tion.