MODULATION BY CASEIN AND SOYBEAN PROTEIN AMINO-ACID MIXTURES OF INSULIN-DEPENDENT AND GLUCAGON-DEPENDENT LINOLEIC-ACID DESATURATION IN PRIMARY-CULTURED RAT HEPATOCYTES

The effects of amino acid mixtures simulating to casein and soybean pr otein on insulin- and glucagon-dependent linoleic acid desaturation we re studied in rat hepatocytes of up to 72 h of culture. The desaturati on increased with the insulin molarity in the medium, but decreased wi th the glucagon molarity. The soybean protein type of amino acid mixtu re, compared to the casein type of amino acid mixture, potentiated the insulin-dependent desaturation. Thus, dietary proteins could moidify in vivo insulin-dependent intracellular metabolism through postprandia l amino acids in blood plasma.