J. Tamaoki et al., MACROLIDE ANTIBIOTICS PROTECT AGAINST ENDOTOXIN-INDUCED VASCULAR LEAKAGE AND NEUTROPHIL ACCUMULATION IN RAT TRACHEA, Antimicrobial agents and chemotherapy, 38(7), 1994, pp. 1641-1643
We studied the effects of macrolides on lipopolysaccharide (LPS)-induc
ed airway inflammation in the rat tracheal mucosa. Erythromycin and ro
xithromycin dose dependently inhibited microvascular leakage and neutr
ophil recruitment induced by LPS. This inhibitory action on vascular p
ermeability was abolished by neutrophil depletion.