MACROLIDE ANTIBIOTICS PROTECT AGAINST ENDOTOXIN-INDUCED VASCULAR LEAKAGE AND NEUTROPHIL ACCUMULATION IN RAT TRACHEA

Authors
TAMAOKI J SAKAI N TAGAYA E KONNO K
Citation
J. Tamaoki et al., MACROLIDE ANTIBIOTICS PROTECT AGAINST ENDOTOXIN-INDUCED VASCULAR LEAKAGE AND NEUTROPHIL ACCUMULATION IN RAT TRACHEA, Antimicrobial agents and chemotherapy, 38(7), 1994, pp. 1641-1643
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
7
Year of publication
1994
Pages
1641 - 1643
Database
ISI
SICI code
0066-4804(1994)38:7<1641:MAPAEV>2.0.ZU;2-5
Abstract
We studied the effects of macrolides on lipopolysaccharide (LPS)-induc ed airway inflammation in the rat tracheal mucosa. Erythromycin and ro xithromycin dose dependently inhibited microvascular leakage and neutr ophil recruitment induced by LPS. This inhibitory action on vascular p ermeability was abolished by neutrophil depletion.