DECREASED COUNTS OF BLOOD NEUTROPHILS, MONOCYTES, AND PLATELETS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN AND YOUNG-ADULTS TREATED WITH DIETHYLDITHIOCARBAMATE

Authors
SHENEP JL HUGHES WT FLYNN PM ROBERSON PK BEHM FG FULLEN GH KOVNAR SG GUITO KP BRODKEY TO
Citation
Jl. Shenep et al., DECREASED COUNTS OF BLOOD NEUTROPHILS, MONOCYTES, AND PLATELETS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN AND YOUNG-ADULTS TREATED WITH DIETHYLDITHIOCARBAMATE, Antimicrobial agents and chemotherapy, 38(7), 1994, pp. 1644-1646
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
7
Year of publication
1994
Pages
1644 - 1646
Database
ISI
SICI code
0066-4804(1994)38:7<1644:DCOBNM>2.0.ZU;2-L
Abstract
Nineteen young human immunodeficiency virus-infected patients were ran domized to receive 400 mg of oral diethyldithiocarbamate (DTC) per m(2 ) or placebo weekly for 12 weeks. Changes in blood CD4(+) lymphocytes were not significantly different between groups. However, neutrophil, monocyte, and platelet counts consistently decreased during DTC treatm ent, suggesting DTC-mediated myelosuppression.