PRODUCTION OF A-VARIANT AND C-VARIANT OF STAPHYLOCOCCAL BETA-LACTAMASE BY METHICILLIN-RESISTANT STRAINS OF STAPHYLOCOCCUS-AUREUS

Authors
NORRIS SR STRATTON CW KERNODLE DS
Citation
Sr. Norris et al., PRODUCTION OF A-VARIANT AND C-VARIANT OF STAPHYLOCOCCAL BETA-LACTAMASE BY METHICILLIN-RESISTANT STRAINS OF STAPHYLOCOCCUS-AUREUS, Antimicrobial agents and chemotherapy, 38(7), 1994, pp. 1649-1650
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
7
Year of publication
1994
Pages
1649 - 1650
Database
ISI
SICI code
0066-4804(1994)38:7<1649:POAACO>2.0.ZU;2-R
Abstract
Most methicillin-resistant Staphylococcus aureus (MRSA) strains produc e beta-lactamase. To determine whether this enzyme(s) is identical to one or more of the four beta-lactamases produced by methicillin-suscep tible strains, the beta-lactamases of 50 MRSA isolates were typed by u sing substrate profile analysis. Forty type A, no type B, ten type C, and no type D beta-lactamase-producing strains mere identified. The be ta-lactamase inhibitor sulbactam reduced the MICs of beta-lactamase-la bile antibiotics, including ampicillin, penicillin G, and cefazolin, f or type A and type C MRSA strains.