INCREASED ACTIVITY OF A NEW CHLOROFLUOROQUINOLONE, BAY-Y-3118, COMPARED WITH ACTIVITIES OF CIPROFLOXACIN, SPARFLOXACIN, AND OTHER ANTIMICROBIAL AGENTS AGAINST ANAEROBIC-BACTERIA

A total of 435 clinical isolates of anaerobes were tested with a broth microdilution method to determine the activity of BAY y 3118 compared with those of other agents against anaerobic bacteria. All strains of Bacteroides capillosus, Prevotella spp., Porphyromonas spp., Fusobact erium spp., Clostridium spp., Eubacterium spp., Peptostreptococcus spp ., and Veillonella parvula were susceptible (MICs of less than or equa l to 2 mu g/ml) to BAY y 3118. Against the 315 strains of the Bacteroi des fragilis group, five strains required elevated MICs (greater than or equal to 4 mu g/ml) of BAY y 3118. Only imipenem and metronidazole were active against all anaerobes. Overall, BAY y 3118 was more active than ciprofloxacin, sparfloxacin, piperacillin; cefotaxime, and clind amycin against the test isolates.