ENDOTHELIN ET(A) AND ET(B) RECEPTORS IN SUBARACHNOID HEMORRHAGE-INDUCED CEREBRAL VASOSPASM

Authors
ZUCCARELLO M LEWIS AI RAPOPORT RM
Citation
M. Zuccarello et al., ENDOTHELIN ET(A) AND ET(B) RECEPTORS IN SUBARACHNOID HEMORRHAGE-INDUCED CEREBRAL VASOSPASM, European journal of pharmacology, 259(1), 1994, pp. 180000001-180000002
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
259
Issue
1
Year of publication
1994
Pages
180000001 - 180000002
Database
ISI
SICI code
0014-2999(1994)259:1<180000001:EEAERI>2.0.ZU;2-6
Abstract
The relative roles of endothelin ET(A) and ET(B) receptor activation i n cerebral vasospasm following subarachnoid hemorrhage were investigat ed in the rabbit. The endothelin ET(A) receptor antagonist, BQ610 (1 m u M; homopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-OH), and the endothelin E T(A)/ET(B) receptor antagonist, PD145065 (1 mu M; Ac-D-Bhg-L-Leu-L-Asp -L-Ile-L-Ile-L-Trp), relaxed the vasospastic basilar artery in situ by 45% and 87%, respectively. These results suggest that subarachnoid he morrhage-induced vasospasm of the rabbit basilar artery is due to acti vation of both endothelin ET(A) and ET(B) receptors.