MAGNETIC-RESONANCE-IMAGING FINDINGS IN VOGT-KOYANAGI-HARADA SYNDROME

Background: Vogt-Koyanagi-Harada Syndrome (VKHS) is a systemic disorde r consisting of bilateral panuveitis with associated cutaneous and neu rologic findings. In the absence of extraocular manifestations, diagno sis of VKHS may be difficult. Methods: The results of magnetic resonan ce imaging (MRI) in two patients with VKHS and of computed tomography (CT) in a third patient with VKHS are described. Results: Bilateral, d iffuse choroidal thickening with scleral sparing was the norm. Choroid al thickening was demonstrable, despite the normal fundus appearance a nd fluorescein angiogram, in one eye. Intense enhancement after admini stration of gadopentetate was seen in the acute stages, but not after corticosteroid treatment. High-intensity periventricular lesions were seen in one patient. Conclusion: MRI superbly discriminates the fibrou s sclera from the choroid and allows for the detection of subclinical ocular and central nervous system disease. It is therefore a useful ad junct in the diagnosis and follow-up of VKHS.