Mg. Gonzalez et al., HEPATITIS DUE TO DROXICAM - DESCRIPTION O F 3 NEW CASES AND LITERATURE-REVIEW, Revista Clinica Espanola, 194(3), 1994, pp. 170-172
Three new cases of cholestatic hepatitis caused by droxicam are descri
bed, along with a revision of the other eight cases published to date.
Itching, asthenia, and jaundice were the most common symptoms. Averag
e age was 62.8 years (range: 45-82 years), and the median time of expo
sition was 22.7 days (range: 5-50 days). Biochemistry of the liver sho
wed primarily cholestasis and in 4/11 cases hypereosinophilia. Two pat
ients presented elevated levels of cholesterol and triglycerides which
disappeared within the month. Clinical manifestations persisted in on
e patient for eight weeks after the cessation of treatment. The three
patients presented in the present series presented alteration in the b
iochemistry of the liver two months after initiation. Liver biopsy in
three patients showed centrozonal cholestasis associated with portal i
nflammatory activity and presence of granulomas consistent with toxic
hepatitis.