Quality-of-life evaluation has gained increasing attention within the
oncology community over the past 2 decades. The breadth of quality-of-
life research in women with breast cancer has expanded substantially d
uring this time. This paper reviews the status of quality-of-life rese
arch in women with breast cancer and explores several areas in which q
uality-of-life research can be of value. Descriptive quality-of-life s
tudies in patients undergoing active treatment can identify the impact
breast cancer treatment has on a patient's life. For patients who hav
e completed treatment, research can detect areas of persistent distres
s. Quality-of-life assessment now is incorporated in many clinical tri
als. These data can provide a patient-rated assessment of treatment an
d complement the traditional endpoints in clinical trials. Examples of
selected quality-of-life studies in patients with breast cancer are p
resented.