Many more young breast cancer patients will be seeking medical advice
about pregnancy, because oophorectomy is no longer performed adjuvantl
y, and more women are bearing children in later years. In the meager a
mount of literature on the topic, it has been observed that breast can
cer patients who subsequently become pregnant have as good a survival
rate as those with no subsequent pregnancy. In particular the case-mat
ching studies attempt to eliminate the obvious factor of pregnancy occ
urring only in those with a good prognosis. Survival in cases with sub
sequent pregnancy is reported in some studies as better than in the co
ntrols with no posttreatment pregnancy. All reports are retrospective,
are composed of small numbers of patients, were gathered over several
decades, and rely on clinicians' memories, because subsequent pregnan
cy has not been recorded systematically. For example, the largest stud
y includes 136 patients accumulated over 50 years. Assuming that only
a small percentage of fertile breast cancer patients become pregnant,
the majority appear to have been ''lost to follow-up'' and unreported.
In summary, the limited literature on pregnancy subsequent to breast
cancer does not allow one to be certain about its effect. Regarding ad
vice to the individual patient who has decided to become pregnant, mos
t clinicians traditionally have recommended a delay of 2 years or more
to allow aggressive disease to become manifest.