THE DEVELOPMENT OF GLIAL FIBRILLARY ACIDIC PROTEIN-POSITIVE CELLS ANDTHE APPEARANCE OF LAMININ-LIKE IMMUNOREACTIVITY IN FETAL OLFACTORY-BULB TRANSPLANTS

Embryonic rat olfactory bulbs were transplanted into the site vacated by aspiration of an olfactory bulb from a neonatal rat. This paper pre sents our findings related to the development of glial fibrillary acid ic protein (GFAP) positive (+ve) glial cells and the appearance of lam inin-like immunoreactivity in these transplants. The GFAP + ve glial c ells formed perivascular end-feet on the invading vasculature and form ed a glia limitans along the pial surface of the transplant. This reco nstituted glia limitans was continuous with that of the host brain, th ere being no glia limitans at the donor-host interface. Thus, the dono r tissue was well-integrated with that of the host brain.