INHIBITION OF ENDOGENOUS DOPAMINE RELEASE IN AMPHIBIAN RETINA BY L-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP(4)) AND TRANS-2-AMINOCYCLOPENTANE-1,3-DICARBOXYLATE (ACPD)

Authors
BOATRIGHT JH GORDON JR IUVONE PM
Citation
Jh. Boatright et al., INHIBITION OF ENDOGENOUS DOPAMINE RELEASE IN AMPHIBIAN RETINA BY L-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP(4)) AND TRANS-2-AMINOCYCLOPENTANE-1,3-DICARBOXYLATE (ACPD), Brain research, 649(1-2), 1994, pp. 339-342
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
649
Issue
1-2
Year of publication
1994
Pages
339 - 342
Database
ISI
SICI code
0006-8993(1994)649:1-2<339:IOEDRI>2.0.ZU;2-Q
Abstract
The metabotropic glutamate receptor agonists 2-amino-4-phosphonobutyri c acid (AP(4)) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD) blocked light-stimulated dopamine release from Xenopus laevis retina. ACPD suppressed release in darkness but AP(4) did not. AP(4) blocked r elease stimulated in darkness by picrotoxin, a GABA-A receptor antagon ist. The data suggest that regulation of dopamine release in Xenopus r etina involves subpopulations of metabotropic glutamate receptors.