Y. Minokoshi et al., REGULATORY MECHANISM OF THE VENTROMEDIAL HYPOTHALAMUS IN ENHANCING GLUCOSE-UPTAKE IN SKELETAL-MUSCLES, Brain research, 649(1-2), 1994, pp. 343-347
To evaluate roles of the sympathetic nervous system in enhancing gluco
se uptake in skeletal muscles in response to electrical stimulation of
the ventromedial hypothalamic nucleus (VMH), the effects of guanethid
ine treatment and adrenal demedullation on the response were examined
in rats anesthetized and injected with muscle relaxant, pancuronium br
omide. Pretreatment with guanethidine effectively suppressed the incre
ase in the rate constant of glucose uptake, measured by the 2-deoxy-D-
[H-3]glucose method, in skeletal muscles upon VMH stimulation. However
, bilateral adrenodemedullation had no significant effect. These resul
ts suggest that the VMH is intimately concerned in the regulation of g
lucose uptake in skeletal muscles through intermediation of the sympat
hetic nerves.