MECHANISTIC DATA AND RISK ASSESSMENT OF SELECTED TOXIC END-POINTS OF THE THYROID-GLAND

Many goitrogenic xenobiotics that increase the incidence of thyroid tu mors in rodents exert a direct effect on the thyroid gland to disrupt one of several possible steps in the biosynthesis, secretion, and meta bolism of thyroid hormones. This includes (a) inhibition of the iodine trapping mechanism, (b) blockage of organic binding of iodine and cou pling of iodothyronines to form thyroxine (T-4) and triiodothyronine ( T-3), and (c) inhibition of thyroid hormone secretion by an effect on proteolysis of active hormone from the colloid. Another large group of goitrogenic chemicals disrupts thyroid hormone economy by increasing the peripheral metabolism of thyroid hormones through an induction of hepatic microsomal enzymes. This group includes central nervous system -acting drugs, calcium channel blockers, steroids, retinoids, chlorina ted hydrocarbons, polyhalogenated biphenyls, and enzyme inducers. Thyr oid hormone economy also can be disrupted by xenobiotics that inhibit the 5'-monodeiodinase that converts T-4 in peripheral sites to biologi cally active T-3. Inhibition of this enzyme by FD&C Red No. 3 lowers c irculating T-3 levels, which results in a compensatory increased secre tion of thyroid stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-yr or lifetime studies in rats. Physiologic perturbations alone, such as the feeding of an iodine-deficient diet, partial thyroidectom y, natural goitrogens in certain foods, and transplantation of TSH-sec reting pituitary tumors in rodents also can disrupt thyroid hormone ec onomy and, if sustained, increase the development of thyroid tumors in rats. A consistent finding with all of these goitrogens, be they eith er physiologic perturbations or xenobiotics, is the chronic hypersecre tion of TSH, which places the rodent thyroid gland at greater risk to develop tumors through a secondary (indirect) mechanism of thyroid onc ogenesis associated with hormonal imbalances.