INTERACTION OF TAXOL AND OTHER ANTICANCER DRUGS WITH HYDROXYPROPYL-BETA-CYCLODEXTRIN

The interaction between 23 anticancer drugs and hydroxypropyl-beta-cyc lodextrin (HP beta CD) was studied by reversed-phase charge-transfer t hin-layer chromatography and the relative strength of interaction was calculated. HP beta CD formed inclusion complexes with 15 compounds, t he complex always being more hydrophilic than the umcomplexed drug. Th e inclusion forming capacity of drugs differed considerably according to their chemical structure. The intensity of interaction significantl y increased with increasing hydrophobicity of the guest molecule, demo nstrating the preponderant role of hydrophobic interactions in inclusi on complex formation.