SYNTHESIS OF GLYCOPEPTIDE DERIVATIVES OF PEPTIDE T ON A SOLID-PHASE USING AN ALLYLIC LINKAGE

Glycopeptides are receiving more and more interest as model compounds for biological and medicinal research. Here we report on a methodology for the synthesis of these complex molecules on a solid phase. Using allylic anchoring groups we are able to construct, detach and isolate the glycopeptides in high yield without affecting any temporary protec ting group or moiety of the conjugate. The strategy and the experiment al data of two syntheses of glycosylated Peptide T, a partial sequence of gp 120 of HIV-1, are described in detail.