STRATEGIES FOR CYCLIZATIONS OF NOVEL PEPTIDES ON SOLID SUPPORTS

Synthetic strategies and methods for the preparation of cyclic peptide s on solid supports are very important for peptide synthesis in genera l, and for the preparation of conformationally constrained biologicall y active peptides. In this paper we report synthetic methods for the p reparation on solid supports of the cyclic and bicyclic biologically a ctive peptides, Ac-[Nle4, Asp5, D-Phe, Lys10]alpha-melanotropin(4-10-N H2, [Lys17, Lys18, Asp21]glucagon-NH2, [beta-Mpa1, Glu4, Cys6, Lys8]ox ytocin and cyclo[Gly-Trp-N-MeNle-Asp-Phe] (cyclic CCK-5 analogue).