THE SEARCH FOR INOSINE 5'-PHOSPHATE DEHYDROGENASE (IMPDH) INHIBITORS FROM MARINE SPONGES - EVALUATION OF THE BASTADIN ALKALOIDS

Authors
JASPARS M RALI T LANEY M SCHATZMAN RC DIAZ MC SCHMITZ FJ PORDESIMO EO CREWS P
Citation
M. Jaspars et al., THE SEARCH FOR INOSINE 5'-PHOSPHATE DEHYDROGENASE (IMPDH) INHIBITORS FROM MARINE SPONGES - EVALUATION OF THE BASTADIN ALKALOIDS, Tetrahedron, 50(25), 1994, pp. 7367-7374
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
25
Year of publication
1994
Pages
7367 - 7374
Database
ISI
SICI code
0040-4020(1994)50:25<7367:TSFI5D>2.0.ZU;2-I
Abstract
Six known bastadins, compounds 1 - 6, and one new one, bastadin 18 (g) , have been isolated from the marine sponge Ianthella Basta collected in Papua New Guinea. A mixture of compounds 2 and 3 was also isolated from I. flabelliformis. Two of these compounds, bastadins 8 (5) and 10 (6), were found to be moderate inhibitors of IMPDH. A discussion of t he enzyme assay is included.