AMINOCHOLESTEROL AND AMINOMETHYLCHOLESTEROL DERIVATIVES WITH FUNGICIDAL ACTIVITY

Authors
ELKIHEL L SOUSTRE I KARST F LETOURNEUX Y
Citation
L. Elkihel et al., AMINOCHOLESTEROL AND AMINOMETHYLCHOLESTEROL DERIVATIVES WITH FUNGICIDAL ACTIVITY, FEMS microbiology letters, 120(1-2), 1994, pp. 163-167
Citations number
15
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
120
Issue
1-2
Year of publication
1994
Pages
163 - 167
Database
ISI
SICI code
0378-1097(1994)120:1-2<163:AAADWF>2.0.ZU;2-P
Abstract
Among a series of aminocholesterol derivatives synthesized, 7-aminocho lesterol is the strongest inhibitor of yeast cell growth. Using sterol auxotrophic mutant strains, we showed that this compound inhibits cel l proliferation by interfering with ergosterol biosynthesis. The stero l pattern of treated cells revealed that 7-aminocholesterol inhibits D elta(8) --> Delta(7)-sterol isomerase and Delta(14)-sterol reductase a s morpholine inhibitors. However, the novel feature of this compound i s a strong cytotoxicity to yeast.