CHARACTERIZATION OF A NEW CASE OF TRISOMY-8 IN ACUTE LYMPHOBLASTIC-LEUKEMIA

Trisomy 8 is a relatively common finding in acute nonlymphoblastic leu kemia (ANLL). In childhood acute lymphoblastic leukemia (ALL) it appar ently is much more rare. Although Human Gene Mapping 11 included triso my 8 os a marker for a subgroup of ALL, morphologic and immunologic ch aracteristics of this entity have not been defined. We describe a case of early T-celI ALL (T-ALL) in a pediatric patient in whom this abnor mality was the sole chromosome aberration. In situ hybridization with a chromosome 8-specific alpha-satellite DNA probe was performed. Our d ata are discussed and compared with pertinent literature.