SEVERE HYPODIPLOIDY WITH KARYOTYPE INSTABILITY IN A CASE OF ACUTE MYELOID-LEUKEMIA

Authors
BETTS DR BAUGH OHA GIBBONS B
Citation
Dr. Betts et al., SEVERE HYPODIPLOIDY WITH KARYOTYPE INSTABILITY IN A CASE OF ACUTE MYELOID-LEUKEMIA, Cancer genetics and cytogenetics, 74(2), 1994, pp. 147-149
Citations number
14
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
74
Issue
2
Year of publication
1994
Pages
147 - 149
Database
ISI
SICI code
0165-4608(1994)74:2<147:SHWKII>2.0.ZU;2-9
Abstract
We present a case of acute myeloid leukemia (AML) in an elderly male. A severe hypodiploid karyotype (chromosome range 29-39) was detected w ith a large amount of cell-to-cell variation, suggesting that the leuk emic cells are primarily characterized by chromosomal loss due to kary otypic instability. Severe hypodiploidy is a rare finding in AML but p revious similar cases indicate that it confers a very poor prognosis.