Nb. Atkin et Mc. Baker, DERIVATIVE CHROMOSOME, DER(17,22)(Q10,Q10), IN 2 CARCINOMAS OF THE CERVIX UTERI AND ONE OF THE SKIN, Cancer genetics and cytogenetics, 74(2), 1994, pp. 153-155
In a previous study, we described 17p+ chromosomes in about 40% of car
cinomas of the cervix, but it was usually not possible to identify the
additional material on the short arm of the chromosome 17. Here we re
port an apparently identical rearranged chromosome in two squamous cel
l carcinomas of the cervix and one of the skin, in which the whole of
17p has been replaced by the long arm of a chromosome 22: der(17;22)(q
10;q10), suggesting that this rearrangement may represent a significan
t step in the development of carcinomas of the cervix and other sites.