SOLID-PHASE SYNTHESIS OF PEPTIDE HYDROXAMIC ACIDS

The synthesis of peptide hydroxamic acids has been performed on a soli d support. A carboxyl group of a peptide synthesized on para-methylben zhydrylamine (pMBHA) resin was converted to a hydroxamate functional g roup by condensing with NH(2)OBzl, which was found preferable to NH(2) OtBu or NH(2)OTrt. The hydroxamate benzyl protecting group was removed subsequently during HF cleavage of the peptide resin. Five peptide hy droxamic acids were prepared according to this new method. (C) 1997 El sevier Science Ltd.