ASYMMETRIC-SYNTHESIS OF IBUPROFEN VIA DIASTEREOSELECTIVE ALKYLATION OF A HOMOCHIRAL N-ACYLBORNANESULTAM

Authors
OPPOLZER W ROSSET S DEBRABANDER J
Citation
W. Oppolzer et al., ASYMMETRIC-SYNTHESIS OF IBUPROFEN VIA DIASTEREOSELECTIVE ALKYLATION OF A HOMOCHIRAL N-ACYLBORNANESULTAM, Tetrahedron letters, 38(9), 1997, pp. 1539-1540
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
9
Year of publication
1997
Pages
1539 - 1540
Database
ISI
SICI code
0040-4039(1997)38:9<1539:AOIVDA>2.0.ZU;2-P
Abstract
A very short, 4 step synthesis of 2-(4-isobutylphenyl)propionic acid ( ibuprofen) was achieved in 57% overall yield, using a highly diastereo selective alkylation of the chiral enolate derived from N-(4-isobutylp henyl)acetyl bornanesultam as a key step. (C) 1997 Elsevier Science Lt d.