PYRROLIDINOPIPERAZINEDIONE AS CHIRAL AUXILIARY AND ITS USE IN ASYMMETRIC MANNICH SYNTHESIS

Authors
GUENOUN F ZAIR T LAMATY F PIERROT M LAZARO R VIALLEFONT P
Citation
F. Guenoun et al., PYRROLIDINOPIPERAZINEDIONE AS CHIRAL AUXILIARY AND ITS USE IN ASYMMETRIC MANNICH SYNTHESIS, Tetrahedron letters, 38(9), 1997, pp. 1563-1566
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
9
Year of publication
1997
Pages
1563 - 1566
Database
ISI
SICI code
0040-4039(1997)38:9<1563:PACAAI>2.0.ZU;2-N
Abstract
Functionalised diketopiperazines (DKPs) are easily obtained optically pure by disymmetrization of a mesopyrrolidine and can be easily conver ted to an alpha-amino amine containing compound. As a first example, o ne of the new chiral auxiliaries has been used to prepare an optically pure beta-amino ester through a Mannich reaction. (C) 1997 Published by Elsevier Science Ltd.