SPERMINE TOXICITY IN BHK-21 C-13 CELLS IN THE PRESENCE OF BOVINE SERUM - THE EFFECT OF AMINOGUANIDINE

Authors
BRUNTON VG GRANT MH WALLACE HM
Citation
Vg. Brunton et al., SPERMINE TOXICITY IN BHK-21 C-13 CELLS IN THE PRESENCE OF BOVINE SERUM - THE EFFECT OF AMINOGUANIDINE, Toxicology in vitro, 8(3), 1994, pp. 337-341
Citations number
19
Categorie Soggetti
Toxicology
Journal title
Toxicology in vitro → ACNP
ISSN journal
08872333
Volume
8
Issue
3
Year of publication
1994
Pages
337 - 341
Database
ISI
SICI code
0887-2333(1994)8:3<337:STIBCC>2.0.ZU;2-E
Abstract
Spermine was toxic to BHK-21/C13 cells in the presence of newborn calf serum and the toxicity, but not the metabolism of spermine, was preve nted by aminoguanidine. Aminoguanidine treatment resulted in significa nt alterations in the polyamine profile of these cells with loss of in tracellular putrescine after 4 hr of exposure. In the presence of amin oguanidine, intracellular polyamine content returned to control values at 24 hr, possibly as a result of increased uptake of exogenous sperm ine.