INFLUENCE OF PH ON RESERVOIR MUCOSAL ABSORPTION SECRETION AND TUBULARAND GLOMERULAR FUNCTION - STUDIES IN PATIENTS WITH A CONTINENT ILEAL RESERVOIR FOR URINARY-DIVERSION/
S. Akerlund et al., INFLUENCE OF PH ON RESERVOIR MUCOSAL ABSORPTION SECRETION AND TUBULARAND GLOMERULAR FUNCTION - STUDIES IN PATIENTS WITH A CONTINENT ILEAL RESERVOIR FOR URINARY-DIVERSION/, Scandinavian journal of urology and nephrology, 28(2), 1994, pp. 141-146
Ten patients with a continent ileal reservoir for urinary diversion we
re studied regarding transmucosal fluxes of water and electrolytes at
different pH. The urine was by-passed;the reservoir via a Foley cathet
er. The experiment set-up was designed to exclude urine from reservoir
mucosa exposition during the study. Test solutions of pH 4 and pH 7 w
ith electrolytes and a non-absorbable volume marker (PEG MW 4000) were
instilled into the empty reservoir. The influence of altered pH on th
e flow of water and Na,(+),K+ and Cl- across the reservoir mucosa was
analysed. The maximal concentration ability after intranasal desmopres
sin (Minirin((R))), the creatinine and Na-clearance as well as the fra
ctional Na-excretion were calculated from measurements on the by-passe
d urine. The results showed a secretion of water, Na+ and Cl- into the
reservoir while the K+ content was constant. The mucosal flows of wat
er and electrolytes were not affected by alterations in reservoir pH.
Maximal concentration ability appeared to be reduced compared to norma
ls. Fractional Na excretion was within normal limits.