A NOVEL HYPOTHESIS - SPECIFIC ONCOGENES AND TUMOR SUPPRESSION GENES ARE INVOLVED IN THE EXPRESSION OF THE PROOPIOMELANOCORTIN GENE BY SMALL-CELL LUNG-CANCER

Authors
AMSLER UJ PASI A QU BX
Citation
Uj. Amsler et al., A NOVEL HYPOTHESIS - SPECIFIC ONCOGENES AND TUMOR SUPPRESSION GENES ARE INVOLVED IN THE EXPRESSION OF THE PROOPIOMELANOCORTIN GENE BY SMALL-CELL LUNG-CANCER, Medical hypotheses, 42(6), 1994, pp. 397-399
Citations number
38
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Medical hypotheses → ACNP
ISSN journal
03069877
Volume
42
Issue
6
Year of publication
1994
Pages
397 - 399
Database
ISI
SICI code
0306-9877(1994)42:6<397:ANH-SO>2.0.ZU;2-9
Abstract
The endogenous opioid beta-endorphin, a derivative of proopiomelanocor tin, stimulates the growth of cloned human small cell lung carcinoma. The present hypothesis states that mutations of the retinoblastoma gen e (a tumor suppressor gene) associated to the malignant transformation of bronchial cells would trigger a cascade of biomolecular events lea ding to 'de novo' proopiomelanocortin expression in small cell lung ca rcinoma.