TRANSIENT NEONATAL DIABETES-MELLITUS - A RELAPSE AFTER 10 YEARS OF COMPLETE REMISSION

The follow-up study of a patient with permanent diabetes (DM) unrelate d to islet cell antibody and anti-insulin antibodies and occurring 10 years after a transient neonatal DM episode is reported. A latent defe ct in insulin release was proved. It produced transient glucosuria dur ing intercurrent illnesses and permanent hyperglycaemia and a decrease in growth velocity [with high stimulated growth hormone and low insul in-like growth factor I (IGF-I)] at the onset of puberty. After insuli n therapy was re-introduced, catch-up growth and normalization of the blood glucose and IGF-I levels were noted.