STRUCTURE AND SEQUENCE OF MOUSE BONE MORPHOGENETIC PROTEIN-2 GENE (BMP-2) - COMPARISON OF THE STRUCTURES AND PROMOTER REGIONS OF BMP-2 AND BMP-4 GENES

Authors
FENG JQ HARRIS MA GHOSHCHOUDHURY N FENG M MUNDY GR HARRIS SE
Citation
Jq. Feng et al., STRUCTURE AND SEQUENCE OF MOUSE BONE MORPHOGENETIC PROTEIN-2 GENE (BMP-2) - COMPARISON OF THE STRUCTURES AND PROMOTER REGIONS OF BMP-2 AND BMP-4 GENES, Biochimica et biophysica acta, N. Gene structure and expression, 1218(2), 1994, pp. 221-224
Citations number
14
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1218
Issue
2
Year of publication
1994
Pages
221 - 224
Database
ISI
SICI code
0167-4781(1994)1218:2<221:SASOMB>2.0.ZU;2-Z
Abstract
Screening of a mouse spleen genomic DNA library with mouse BMP-4 and B MP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene c ontains similar to 11 kb transcription unit and 3 exons. The deduced p rotein has 394 amino acids. The C-terminal amino acid mature coding re gion is identical to that of the human BMP-2. Comparison of mouse BMP- 2 and BMP-4 gene shows little similarity in exon/intron structure, alt hough the mature coding peptide regions of both genes share over 90% i dentity at the amino acid level.