INDUCTION OF OXYGEN-FREE RADICAL GENERATION IN HUMAN MONOCYTES BY LIPOPROTEIN(A)

Authors
HANSEN PR KHARAZMI A JAUHIAINEN M EHNHOLM C
Citation
Pr. Hansen et al., INDUCTION OF OXYGEN-FREE RADICAL GENERATION IN HUMAN MONOCYTES BY LIPOPROTEIN(A), European journal of clinical investigation, 24(7), 1994, pp. 497-499
Citations number
15
Categorie Soggetti
Medicine, Research & Experimental
Journal title
European journal of clinical investigation → ACNP
ISSN journal
00142972
Volume
24
Issue
7
Year of publication
1994
Pages
497 - 499
Database
ISI
SICI code
0014-2972(1994)24:7<497:IOORGI>2.0.ZU;2-F
Abstract
The mechanism behind the association of elevated plasma lipoprotein(a) [Lp(a)l levels with atherosclerotic disease is unknown. In the presen t study, Lp(a) induced generation of oxygen free radicals by monocytes from selected healthy individuals in vitro. This observation may prov ide a link between Lp(a) and generation of oxidized LDL, which can pro mote multiple atherogenic cellular responses.