Re. Mccue et J. Aronowitz, ACCELERATED ANTIDEPRESSANT RESPONSE IN GERIATRIC INPATIENTS, The American journal of geriatric psychiatry, 2(3), 1994, pp. 244-246
Six elderly depressed inpatients were treated for 2 weeks with low dos
es of nortriptyline and fluoxetine in combination. All patients showed
significant reductions in depressive symptoms with minimal side effec
ts. Clinical improvement appeared unrelated to whether plasma levels o
f nortriptyline were therapeutic. The implications of this regimen for
accelerated antidepressant response as well as the limitations of thi
s report are discussed.