INHIBITION BY CATECHOL AND DI(2-ETHYLHEXYL)PHTHALATE OF PANCREATIC CARCINOGENESIS AFTER INITIATION WITH N-NITROSOBIS(2-HYDROXYPROPYL)AMINE IN SYRIAN-HAMSTERS

The effects of dietary administration of catechol (CC), paramethylcate chol (PMC) and di(2-ethylhexyl)phthalate (DEHP) were compared with tha t of butylated hydroxyanisole (BHA) in Syrian hamsters initiated with N-nitrosobis(2-hydroxypropyl)amine (BHP). Development of pancreatic at ypical hyperplasias and adenocarcinomas in terms of combined multiplic ity was significantly reduced by CC and DEHP. A similar slight but non -significant tendency was observed for BHA, while PMC was without effe ct. No statistically significant reduction of liver or gall bladder le sions was observed. The results thus suggest that both antioxidant and peroxisome proliferator categories of agents can inhibit pancreatic c arcinogenesis in hamsters.