X-CHROMOSOME INACTIVATION - MOLECULAR MECHANISMS AND GENETIC CONSEQUENCES

Authors
MIGEON BR
Citation
Br. Migeon, X-CHROMOSOME INACTIVATION - MOLECULAR MECHANISMS AND GENETIC CONSEQUENCES, Trends in genetics, 10(7), 1994, pp. 230-235
Citations number
51
Categorie Soggetti
Genetics & Heredity
Journal title
Trends in genetics → ACNP
ISSN journal
01689525
Volume
10
Issue
7
Year of publication
1994
Pages
230 - 235
Database
ISI
SICI code
0168-9525(1994)10:7<230:XI-MMA>2.0.ZU;2-B
Abstract
Mammalian X-chromosome inactivation results in dosage compensation for X-linked genes. More than 30 years after its discovery, the molecular bases of this inactivation are being revealed. Multiple mechanisms ar e responsible for the initiation of this developmental event and the m aintenance of the inactive state. Somatic cellular mosaicism, which is the genetic consequence of X-chromosome inactivation, has a profound influence on the phenotype of mammalian females.