TETRODOTOXIN-BLOCKABLE DEPOLARIZATION-ACTIVATED NA-CELL LINE DERIVED FROM RAT INTERLOBAR ARTERY AND HUMAN UMBILICAL VEIN( CURRENTS IN A CULTURED ENDOTHELIAL)

Authors
GORDIENKO DV TSUKAHARA H
Citation
Dv. Gordienko et H. Tsukahara, TETRODOTOXIN-BLOCKABLE DEPOLARIZATION-ACTIVATED NA-CELL LINE DERIVED FROM RAT INTERLOBAR ARTERY AND HUMAN UMBILICAL VEIN( CURRENTS IN A CULTURED ENDOTHELIAL), Pflugers Archiv, 428(1), 1994, pp. 91-93
Citations number
8
Categorie Soggetti
Physiology
Journal title
Pflugers Archiv → ACNP
ISSN journal
00316768
Volume
428
Issue
1
Year of publication
1994
Pages
91 - 93
Database
ISI
SICI code
0031-6768(1994)428:1<91:TDNLDF>2.0.ZU;2-7
Abstract
Voltage-dependent Na+ current (I-Na) was identified in cultured endoth elial cells derived from rat interlobar artery (RIAE cells) and human umbilical vein (HUVE cells). Tetrodotoxin (TTX) reduced I-Na in a dose -dependent manner with the apparent dissociation constant (K-d) of 1.4 mu M. Low sensitivity of I-Na to TTX as well as its kinetics and volt age-dependent properties indicates that voltage-gated Na channels expr essed in vascular endothelial cells belong to the so-called TTX-resist ant type [2].