UP-REGULATION OF ACTIN GENE-EXPRESSION IN CELLS EXPRESSING EXOGENOUS BETA-AMYLOID PRECURSOR PROTEIN

Authors
RAMAKRISHNA N SMEDMAN M RAMAKRISHNA V GILLAM B
Citation
N. Ramakrishna et al., UP-REGULATION OF ACTIN GENE-EXPRESSION IN CELLS EXPRESSING EXOGENOUS BETA-AMYLOID PRECURSOR PROTEIN, Biochemical and biophysical research communications, 231(3), 1997, pp. 615-618
Citations number
16
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
231
Issue
3
Year of publication
1997
Pages
615 - 618
Database
ISI
SICI code
0006-291X(1997)231:3<615:UOAGIC>2.0.ZU;2-D
Abstract
We investigated the effects of beta-amyloid peptide precursor (APP) ov erexpression upon the levels of other mRNAs. Using quantitative slot-b lot hybridization and immunoblot analysis we observed that enhanced le vels of APP elevated the levels of beta-actin and beta-actin mRNA, Our results also suggest that the cytoplasmic domain of APP is crucial fo r the elevation in beta-actin gene expression. (C) 1997 Academic Press .