HIGH ENANTIOSELECTIVE HYDROGENATION OF ALPHA-BETA-UNSATURATED CARBOXYLIC-ACIDS CATALYZED BY H(8)-BINAP-RU(II) COMPLEXES

Authors
ZHANG XY UEMURA T MATSUMURA K SAYO N KUMOBAYASHI H TAKAYA H
Citation
Xy. Zhang et al., HIGH ENANTIOSELECTIVE HYDROGENATION OF ALPHA-BETA-UNSATURATED CARBOXYLIC-ACIDS CATALYZED BY H(8)-BINAP-RU(II) COMPLEXES, Synlett, (7), 1994, pp. 501-503
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
7
Year of publication
1994
Pages
501 - 503
Database
ISI
SICI code
0936-5214(1994):7<501:HEHOAC>2.0.ZU;2-X
Abstract
Asymmetric hydrogenation of a series of alpha,beta-unsaturated carobxy lic acids catalyzed by the H8-BINAP-Ru(II) complexes, Ru(OCOCH3)2[(S)- H8-binap] and (RuI((R)-H8-binap)(p-cymene)]I [H8-BINAP = no)-5,5',6,6' ,7,7',8,8'octahydro-1,1'-binaphthyl], affords the corresponding satura ted carboxylic acids in excellent enantioselectivities (86-97%). This reaction has also been applied to the synthesis of (S)-ibuprofen in 97 % ee.