Gd. Prell et Jp. Green, MEASUREMENT OF HISTAMINE METABOLITES IN BRAIN AND CEREBROSPINAL-FLUIDPROVIDES INSIGHTS INTO HISTAMINERGIC ACTIVITY, Agents and actions, 41, 1994, pp. 30000005-30000008
Measurements of the concentrations of histamine's metabolites, tele-me
thylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), in
brain have been used to evaluate histamine turnover in brains of anima
ls, and the same measurements in CSF have been used to infer histamine
rgic activity in brains of man. In regions of rat brain, half-lives of
histamine are shorter than those of dopamine, 5-hydroxytryptamine and
norepinephrine. Studies of human CSF suggest that brain histaminergic
activity increases with age and is higher in females than in males.