Pm. Shah et al., EFFECTS OF THE H-2-ANTAGONISTS FAMOTIDINE AND NIZATIDINE AND THE CYTOPROTECTANT MISOPROSTOL ON HUMAN COLONIC AND RAT PERITONEAL MAST-CELLS, Agents and actions, 41, 1994, pp. 30000051-30000052
The Hz-antagonists famotidine and nizatidine produced a dose-dependent
inhibition of histamine release from human colonic mucosal and muscle
mast cells stimulated with anti-IgE. The IC30 values were in the rang
e 0.5-10 mu M and the maximum inhibition approached 50%. The compounds
showed similar efficacy against rat peritoneal mast cells but were mo
re potent. The cytoprotectant misoprostol had a striking effect on the
human colonic mast cells, producing more than 50% inhibition at conce
ntrations of 0.1-1 nM, but was much less active against the rat cells.