Jz. Nowak et B. Sek, HISTAMINE IS A POWERFUL STIMULATOR OF CYCLIC-AMP FORMATION IN CHICK PINEAL-GLAND, Agents and actions, 41, 1994, pp. 30000060-30000061
Histamine(HA) potently stimulated both basal and forskolin-activated c
AMP formation in chick pineal gland. The action of HA was mimicked by
4-methyl-HA, and to some extent by 2-methyl-HA and 2-thiazolylethylami
ne (2TEA), but not by dimaprit, (R)-alpha-methyl-HA tele-methyl-HA and
several other imidazole-derivatives. The stimulatory actions of all t
he compounds were antagonized by ranitidine and tiotidine (HA H-2-rece
ptor antagonists), and were not affected by mepyramine and thioperamid
e (HA H-1- and H-3-receptor blockers, respectively). These data indica
te that the chick pineal probably contains H-2-like HA receptors, whos
e stimulation leads to increases in cAMP production.