A. Gadekmichalska et al., PITUITARY-ADRENOCORTICAL RESPONSIVENESS TO HISTAMINERGIC STIMULATION DURING SOCIAL STRESS OF CROWDING IN RATS, Agents and actions, 41, 1994, pp. 30000080-30000081
Social stress of crowding for 3, 7, 14 and 21 days drastically reduces
the serum corticosterone response to intracerebroventricular administ
ration of dimaprit, a histamine H-2-receptor agonist, moderately dimin
ishes the response to pyridylethylamine, an H-1-receptor agonist, and
does not change significantly the corticosterone response to histamine
. These results suggest that social stress of crowding considerably de
sensitizes central histamine H-2-receptors involved in stimulation of
the hypothalamic-pituitary-adrenal axis.