PITUITARY-ADRENOCORTICAL RESPONSIVENESS TO HISTAMINERGIC STIMULATION DURING SOCIAL STRESS OF CROWDING IN RATS

Citation
A. Gadekmichalska et al., PITUITARY-ADRENOCORTICAL RESPONSIVENESS TO HISTAMINERGIC STIMULATION DURING SOCIAL STRESS OF CROWDING IN RATS, Agents and actions, 41, 1994, pp. 30000080-30000081
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00654299
Volume
41
Year of publication
1994
Pages
30000080 - 30000081
Database
ISI
SICI code
0065-4299(1994)41:<30000080:PRTHSD>2.0.ZU;2-E
Abstract
Social stress of crowding for 3, 7, 14 and 21 days drastically reduces the serum corticosterone response to intracerebroventricular administ ration of dimaprit, a histamine H-2-receptor agonist, moderately dimin ishes the response to pyridylethylamine, an H-1-receptor agonist, and does not change significantly the corticosterone response to histamine . These results suggest that social stress of crowding considerably de sensitizes central histamine H-2-receptors involved in stimulation of the hypothalamic-pituitary-adrenal axis.