GASTRIC-ACID AND HISTAMINE-SECRETION IN PATIENTS ON CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS (CAPD)

Gastric secretion was measured in patients with chronic renal failure (CRF) on continuous ambulatory peritoneal dialysis (CAPD), non-uraemic patients with a duodenal ulcer (DU), and healthy volunteers (HV). Bas al acid outputs were not significantly different in the three groups. Under pentagastrin stimulation, acid secretion was lower in CAPD patie nts than in DU patients (p<0.02) but not different from HV controls. B etween CAPD and DU, basal histamine secretion measured in the gastric juice was not different, but the concentration in blood plasma was sig nificantly lower in the CAPD group (p<0.05). Under pentagastrin stimul ation, gastric histamine output and plasma histamine concentration wer e significantly lower in CAPD patients (p<0.05, respectively). Both ba sal and pentagastrin-stimulated gastric acid and histamine outputs wer e directly related. These results suggest that CAPD patients do not ha ve an increased risk of developing DU, but may need acid blockade if t hey are treated for hyperphosphataemia with aluminium containing drugs .