SYSTEMIC AND PULMONARY HEMODYNAMIC-EFFECTS OF INTRAVENOUS-INFUSION OFNONIONIC ISOOSMOLAR DIMERIC CONTRAST-MEDIA - AN INVESTIGATION IN THE PIG OF 2 RATIO 6 CONTRAST-MEDIA

The systemic and pulmonary haemodynamic effects of i.v. infusion (1 ml /s) of high doses (4 ml/kg) of 2 non-ionic, isoosmolar dimeric contras t media (CM) were investigated in 17 female pigs. The 2 CM were iodixa nol and iotrolan. Both CM induced a significant increase of the follow ing parameters: mean arterial, mean right atrial, mean pulmonary arter ial, mean pulmonary arterial occlusion pressure, cardiac output, strok e volume, and diuresis. The plasma concentration of atrial natriuretic peptide was significantly increased following infusion of the 2 CM. A significant decrease was seen in the systemic and pulmonary vascular resistance.